Coverage by GC
Navigate to position chr21:19,611,925-19,631,555:
Note that the range contains areas where coverage drops to zero in a few places.
Enable the collapsed view: Click the track’s gear icon on the right and choose the Display mode: squish.
Next, we’ll load a track that contains information about GC content across the genome (in IGV Desktop, this would be under File > Load from server)
Note the concordance of coverage with GC content.
Question
Why are there blue and red reads throughout the alignments?